菅原卓也(Takuya SUGAHARA)



学術論文

  1. Syntheses of cytotoxic novel arctigenin derivatives bearing halogen and alkyl groups on aromatic rings., Bioorg. Med. Chem. Lett., In press, 2017.
  2. Immunostimulatory effect of aqueous extract of Coriandrum sativum L. seed on macrophages., J. Sci. Food Agr., In press, 2017.
    [PubMed 28369918]
  3. Immunomodulatory activity of octenyl succinic anhydride modified porang (Amorphophallus oncophyllus) glucomannan on mouse macrophage-like J774.1 cells and mouse primary peritoneal macrophages., Molecules, 22(7), E1187, 2017.
    [PubMed 28714872]
  4. Effect of mandarin orange yogurt on allergic conjunctivitis induced by conjunctival allergen challenge., Invest. Ophth. Vis. Sci., 58, 2922-2929, 2017.
    [PubMed 28593244]
  5. Immunostimulatory effect of dried bonito extract on mouse Macrophage cell lines and mouse primary peritoneal macrophages., Cytotechnology, 69, 229-244, 2017.
    [PubMed 28084562]
  6. Suppressive effect of ethanol extract from passion fruit seeds on IgE production., J. Funct. Foods, 32, 176-184, 2017.
  7. Immunostimulatory activity of snake fruit peel extract on murine macrophage-like J774.1 cells., Cytotechnology, 68, 1737-1745, 2016.
    [PubMed 26482737]
  8. Efficacy of chlorophyll c2 for seasonal allergic rhinitis; single-center double blind randomized control trial., Eur. Arch. Oto Rhino Laryngol., 273, 4289-4294, 2016.
    [PubMed 27277115]
  9. Nobiletin suppresses monocyte chemoattractant protein-1 (MCP-1) expression by regulating MAPK signalling in 3T3-L1 cells., J. Funct. Foods, 27, 406-415, 2016.
    [ScinceDirect]
  10. Inhibitory effects of enzyme-treated dried sardine extract on IgE-mediated degranulation of RBL-2H3 cells and a murine model of Japanese cedar pollinosis., RSC Advances, 6, 85718-85726, 2016.
  11. Immunostimulatory effect of spinach aqueous extract on mouse macrophage-like J774.1 cells and mouse primary peritoneal macrophages., Biosci. Biotechnol. Biochem., 80, 1393-1402, 2016.
    [PubMed 27095137]
  12. Effects of an equol-producing bacterium isolated from human feces on isoflavone and lignan metabolism in mice., J. Sci. Food Agr., 96, 3126-3132, 2016.
    [PubMed 26455424]
  13. Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids., Bioorg. Med. Chem. Lett., 26, 3019-3023, 2016.
    [PubMed 27210431]
  14. Effect of concurrent administration of nobiletin and β-lactoglobulin on the symptoms of Japanese cedar pollinosis models in mice., J. Funct. Foods, 22, 389-397, 2016.
    [ScinceDirect]
  15. Effect of the structure of dietary epoxylignan on its cytotoxic activity: relationship between the structure and the activity of 7,7'-epoxylignan and the introduction of apoptosis by caspase 3/7., Biosci. Biotechnol. Biochem., 80, 669-675, 2016.
    [PubMed 26786026]
  16. Methoxychlor enhances degranulation of murine mast cells by regulating FcεRI-mediated signal transduction., J. Immunotoxicol., 12, 283-289, 2015.
    [PubMed 25418051]
  17. Jellyfish collagen stimulates maturation of mouse bone marrow-derived dendritic cells., J. Funct. Foods, 14, 308-317, 2015.
    [ScinceDirect]
  18. Ishizuchi dark tea suppresses IgE-mediated degranulation of RBL-2H3 cells and nasal rubbing behavior of pollinosis in mice., J. Funct. Foods, 14, 659-669, 2015.
    [ScinceDirect]
  19. Revised stereochemistry of ficifolidione and its biological activities against insects and cells., J. Nat. Prod., 78, 43-49, 2015.
    [PubMed 25495518]
  20. Acute larvicidal activity against mosquitoes and oxygen consumption inhibitory activity of dihydroguaiaretic acid derivatives., J. Agric. Food Chem., 63, 2442-2448, 2015.
    [PubMed 25669766]
  21. Cytotoxic activity of butane type of 1,7-seco-2,7'-cyclolignanes and apoptosis induction by caspase 9 and 3., Bioorg. Med. Chem. Lett., 24, 4231-4235, 2014.
    [PubMed 25124113]
  22. Antiproliferative activity and its underlying mechanisms of methanol extract from leaves of Saururus chinensis (Lour.) Baill. on mouse Colon-26 carcinoma cells., Int. J. Appl. Res. Nat. Prod., 7(3), 17-27, 2014.
  23. Activation of J774.1 murine macrophages by lactate dehydrogenase., Cytotechnology, 66, 937-943, 2014.
    [PubMed 24101442]
  24. The major whey protein β-lactoglobulin inhibits IgE-mediated degranulation of RBL-2H3 cells and passive cutaneous anaphylaxis in mice., Int. Dairy J., 39, 89-95, 2014.
    [ScienceDirect]
  25. Studies on anti-allergic activity of Sargassum horneri extract., J. Funct. Foods, 10, 154-160, 2014.
    [ScienceDirect]
  26. Activation of macrophages stimulated by bengkoang fiber extract through Toll-like receptor 4., Food Funct., 5, 1403-1408, 2014.
    [PubMed 24770453]
  27. Tributyltin induces cell cycle arrest at G1 phase in the yeast Saccharomyces cerevisiae., J. Toxicol. Sci., 39, 311-317, 2014.
    [PubMed 24646713]
  28. Nobiletin, a polymethoxy flavonoid, exerts anti-allergic effect by suppressing activation of phosphoinositide 3-kinase., J. Funct. Foods, 6, 606-614, 2014.
    [ScienceDirect]
  29. Jellyfish collagen stimulates production of TNF-α and IL-6 by J774.1 cells through activation of NF-kappaB and JNK via TLR4 signaling pathway., Mol. Immunol., 58, 32-37, 2014.
    [PubMed 24291243]
  30. Immunomodulatory activity of bengkoang (Pachyrhizus erosus) fiber extract in vitro and in vivo., Cytotechnology, 66, 75-85, 2014.
    [PubMed 23361525]
  31. Quantitative structure-activity relationship analysis of antifungal (+)-dihydroguaiaretic acid using 7-phenyl derivatives., J. Agric. Food. Chem., 61, 8546-8555, 2013.
    [PubMed 23924382]
  32. Structure-cytotoxic activity relationship of sesquilignan, Morinol A., Bioorg. Med. Chem. Lett., 23, 4923-4930, 2013.
    [PubMed 23896495]
  33. Phenylhydroquinone induces loss of thymocytes through cell cycle arrest and apoptosis elevation in p53-dependent pathway., J. Toxicol. Sci., 38, 325-335, 2013.
    [PubMed 23665931]
  34. Effect of bengkoang (Pachyrhizus erosus) fiber extract on murine macrophage-like J774.1 cells and mouse peritoneal macrophages., J. Funct. Foods, 5, 204-210, 2013.
    [ScienceDirect]
  35. Inhibitory effect of chlorophyll c2 from brown algae, Sargassum horneri, on degranulation of RBL-2H3 cells., J. Funct. Foods, 5, 204-210, 2013.
    [ScienceDirect]
  36. Inhibitory effect of aqueous spinach extract on degranulation of RBL-2H3 cells., Food Chem., 136, 322-327, 2013.
    [ScienceDirect]
    [PubMed 23122065]
  37. ラット好塩基球様細胞株RBL-2H3の脱顆粒に及ぼすカゼイン由来ペプチドおよび関連アミノ酸の影響, 日本食品科学工学会誌, 59, 556-561, 2012.
  38. Effect of substituents at phenyl group of 7,7'-dioxo-9,9'-epoxylignane on antifungal activity., Bioorg. Med. Chem. Lett., 22, 6740-6744, 2012.
    [PubMed 23017887]
  39. Concerted actions of the catechol o-methyltransferase and the cytosolic sulfotransferase SULT1A3 in the metabolism of catecholic drugs., Biochem. Pharmacol., 84, 1186-1195, 2012.
    [PubMed 22917559]
  40. Immunomodulatory effects of lactate dehydrogenase in vitro and in vivo., J. Funct. Foods, 4, 972-978, 2012.
    [ScienceDirect]
  41. Immunomodulatory effects of citrus fruit auraptene in vitro and in vivo., J. Funct. Foods, 4, 883-890, 2012.
    [ScienceDirect]
  42. Immunochromatographic assay of cadmium levels in oysters., Talanta, 97, 262-266, 2012.
    [ScienceDirect]
  43. Immunostimulatory effect of beta-cryptoxanthin in vitro and in vivo., J. Funct. Foods, 4, 618-625, 2012.
    [ScienceDirect]
  44. Effect of collagens from jellyfish and bovine Achilles tendon on the activity of J774.1 and mouse peritoneal macrophage cells., J. Funct. Foods, 4, 504-512, 2012.
    [ScienceDirect]
  45. Immunostimulatory effects of water extract from bulbus arteriosus in tuna in vitro., J. Funct. Foods, 4, 263-270, 2012.
    [ScienceDirect]
  46. Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction., Biochim. Biophys. Acta - Gen. Subjects, 1820, 461-468, 2012.
    [PubMed 22172985]
  47. Evaluation of immunostimulatory effect of the arrowroot (Maranta arundinacea. L) in vitro and in vivo., Cytotechnology, 64, 131-137, 2012.
    [PubMed 22038480]
  48. (-)-Secoisolariciresinol attenuates high-fat diet-induced obesity in C57BL/6 mice., Food Funct., 3, 76-82, 2012.
    [PubMed 22030618]
  49. Immunostimulatory effects of collagen from jellyfish in vivo., Cytotechnology, 63, 481-492, 2011.
    [PubMed 21773823]
  50. Heavy oil fraction induces the dysplastic sperm in male mouse., J. Toxicol. Sci., 36, 487-491, 2011.
    [PubMed 21804313]
  51. Disruption of ion homeostasis by verrucosin and its related compound., Biosci. Biotechnol. Biochem., 75, 1000-1002, 2011.
    [PubMed 21597167]
  52. Immunomodulatory effect of (-)-matairesinol in vivo and ex vivo., Biosci. Biotechnol. Biochem., 75, 859-863, 2011.
    [PubMed 21597179]
  53. Immunostimulation effects of yellowtail heart extracts in vitro and in vivo., Biosci. Biotechnol. Biochem., 75, 638-645, 2011.
    [PubMed 21512243]
  54. Inhibition of myotube formation by paraquat in the myoblast cell line C2C12., J. Toxicol. Sci., 36, 243-246, 2011.
    [PubMed 21467752]
  55. Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe., J. Toxicol. Sci. , 243-246, 2011.
    [PubMed 21467752]

  56. Immunostimulatory in vitro and in vivo effects of a water-soluble extract from kale., Biosci. Biotechnol. Biochem., 75, 40-46, 2011.
    [PubMed 21228486]
  57. Antifungal activity of morinol B derivatives of tetrahydropyran sesquilignan., Biosci. Biotechnol. Biochem., 74, 2071-2076, 2010.
    [PubMed 20944407]
  58. IgE suppressive activity of (-)-matairesinol and structure-activity relationship., Biosci. Biotechnol. Biochem., 74, 1878-1883, 2010.
    [PubMed 20834158]
  59. Improved syntheses of Morinol C and D by employing Mizoroki-Heck reaction and their cytotoxic and antimicrobial activities., Biosci. Biotechnol. Biochem., 74, 1641-1644, 2010.
    [PubMed 20699576]
  60. The effect of secoisolariciresinol on 3T3-L1 adipocytes and the relationship between molecular structure and the activity., Animal Cell Technology: Basic & Applied Aspects, Vol. 16, 345-351, 2010.

  61. The effects of pesticides on immune cells., Animal Cell Technology: Basic & Applied Aspects, Vol. 16, 377-382, 2010.

  62. The differentiation of myoblast cells to myotube by paraquat., Animal Cell Technology: Basic & Applied Aspects, Vol. 16, 215-219, 2010.

  63. Proteose peptone fraction of bovine milk depressed IgE production in vitro and in vivo., Biosci. Biotechnol. Biochem., 74, 1332-1337, 2010.
    [PubMed 20622462]
  64. Zebrafish as a model for the study of the phase II cytosolic sulfotransferases., Curr. Drug Metab., 11, 538-546, 2010.
    [PubMed 20545621]
  65. In vitro and in vivo anti-tumor effects of novel Span 80 vesicles containing immobilized Eucheuma serra agglutinin., Int. J. Pharm., 389, 157-167, 2010.
    [PubMed 20100554]
  66. Oral administration of paraquat perturbs immunoglobulin productivity in mouse., J. Toxicol. Sci., 35, 257-263, 2010.
    [PubMed 20371979]
  67. Tributyltin induces Yca1p-dependent cell death of the yeast Saccharomyces cerevisiae., J. Toxicol. Sci., 34, 541-545, 2009.
    [J-STAGE]
  68. Heavy oil fractions induce the negative influences on mouse immune system., J. Toxicol. Sci., 34, 459-468, 2009.
    [J-STAGE]
  69. White sorghum (Sorghum bicolor (L.) Moench) bran extracts suppressed IgE production by U266 cells., Biosci. Biotechnol. Biochem., 73, 2043-2047, 2009.
    [PubMed 19734654]
  70. Antimicrobial activity of stereoisomers of butane type of lignans., Biosci. Biotechnol. Biochem., 73, 1806-1810, 2009.
    [PubMed 19661689]
  71. Inhibition of discoloration of yellowtail dark muscle by lignan., Biosci. Biotechnol. Biochem., 73, 1718-1721, 2009.
    [PubMed 19661688]
  72. Syntheses and antimicrobial activity of tetrasubstituted tetrahydrofuran lignan stereoisomers., Biosci. Biotechnol. Biochem., 73, 1608-1617, 2009.
    [PubMed 19584535]

  73. Abnormal response induced by pesticides on mammalian immune system., Interdisciplinary Studies on Environmental Chemistry Vol.2: Environmental Research in Asia for Establishing a Scientist's Network., 211-218, 2009.

  74. Paraquat modulates the differentiation of C2C12 cells to myotube., Interdisciplinary Studies on Environmental Chemistry Vol.2: Environmental Research in Asia for Establishing a Scientist's Network., 219-226, 2009.

  75. Severe abnormalities in the reproductive organs of mice caused by the chemical substances contained in heavy oil., J. Toxicol. Sci., 34, 239-244, 2009.
    [J-STAGE]

  76. Antimicrobial activity of stereoisomers of morinol A and B, tetrahydropyran sesquineolignan., Biosci. Biotechnol. Biochem., 73,129-133, 2009.
    [PubMed 19129639]

  77. The Effect of secoisolariciresinol on 3T3-L1 adipocytes and the relationship between molecular structure and the activity., Biosci. Biotechnol. Biochem., 73, 35-39, 2009.
    [PubMed 19129664]

  78. Characterization of amino acid recycling process in yeast autophagy., Interdisciplinary Studies on Environmental Chemistry: Biological Responses to Chemical Pollutants., 241-249, 2008.
  79. Vacuolar-type H+-translocating ATPase is the target of tributyltin chloride., Interdisciplinary Studies on Environmental Chemistry: Biological Responses to Chemical Pollutants., 251-261, 2008.
  80. Risk assessment of heavy oil on terrestrial mammals., Interdisciplinary Studies on Environmental Chemistry Vol.1: Biological Responses to Chemical Pollutants., 269-274, 2008.
  81. The structure-activity relationship of flaxseed lignan, secoisolariciresinol., Interdisciplinary Studies on Environmental Chemistry Vol.1: Biological Responses to Chemical Pollutants., 263-268, 2008.
  82. Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7'-oxodihydroguaiaretic acid., Biosci. Biotechnol. Biochem., 72, 2981-2986, 2008.
    [PubMed 18997397]

  83. The mode of action of the immunostimulatory effect of collagen from jellyfish., Biosci. Biotechnol. Biochem., 72, 2809-0814, 2008.
    [PubMed 18997433]

  84. Syntheses of all stereoisomers of goniodiol from yeast-reduction products and their antimicrobiological activity., Biosci. Biotechnol. Biochem., 72, 2342-2352, 2008.
    [PubMed 18776681]

  85. Immunostimulation effect of the jellyfish collagen., Animal Cell Technology: Basic & Applied Aspects, Vol. 15, 307-313, 2008.

  86. Structure-antibacterial activity relationship of 9-O,9'-O-demethyl (+)-virgatusin., Biosci. Biotechnol. Biochem., 72, 1032-1037, 2008.
    [PubMed 18391445]

  87. Effects of polyamines on proliferation and IgM productivity of human-human hybridoma, HB4C5 cells., Cytotechnology, 57, 115-122, 2008.
    [PubMed 19003155]

  88. Stereoselective construction of tetra-substituted tetrahydrofuran compounds from benzylic hemiacetal in the presence of H2 and Pd catalyst: stereoselective synthesis of stereoisomer of (-)-virgatusin and antimicrobiological activity., Biosci. Biotechnol. Biochem., 72, 197-203, 2008.
    [PubMed 18175922]

  89. First stereoselective synthesis of meso-secoisolariciresinol and comparison of biological activity with (+) and (-)-secoisolariciresinol., Biosci. Biotechnol. Biochem., 71, 2962-2968, 2007.
    [PubMed 18071272]

  90. Effect of benzylic structure of lignan on antioxidant activity., Biosci. Biotechnol. Biochem., 71, 2283-2290, 2007.
    [PubMed 17827687]

  91. Use of benzyl mesylate for the synthesis of tetrahydrofuran lignan: syntheses of 7,8-trans, 7',8'-trans, 7,7'-cis, 8,8'-cis-virgatusin stereoisomers., Biosci. Biotechnol. Biochem., 71, 2248-2255, 2007.
    [PubMed 17827688]

  92. Antimicrobiological activity of lignan: Effect of benzylic oxygen and stereochemistry of 2,3-dibenzyl-4-butanolide and 3,4-dibenzyltetrahydrofuran lignans on activity., Biosci. Biotechnol. Biochem., 71, 1745-1751, 2007.
    [PubMed 17617715]

  93. Determination of the stereochemistry of the tetrahydropyran sesquineolignans morinol A and B., J. Nat. Prod., 70, 549-556, 2007.
    [PubMed 17302455]

  94. Antifungal activity of tetra-substituted tetrahydrofuran lignan, (-)-virgatusin, and its structure-activity relationship., Biosci. Biotechnol. Biochem., 71, 1028-1035, 2007.
    [PubMed 17420596]

  95. Antibacterial activity of virgatusin-related compound., Biosci. Biotechnol. Biochem., 71, 677-680, 2007.
    [PubMed 17341839]

  96. Effect of benzylic oxygen on the cytotoxic activity of phenolic lignans., Biosci. Biotechnol. Biochem., 70, 2942-2947, 2006.
    [PubMed 17151475]

  97. Immunostimulation effect of the jellyfish collagen., Biosci. Biotechnol. Biochem., 70, 2131-2137, 2006.
    [PubMed 16960386]

  98. The anti-tumor effect of Euchema serra agglutinin (ESA) on colon cancer cells in vitro and in vivo., Anti-Cancer Drug., 17, 943-947, 2006.
    [PubMed 16940804]

  99. Radical and superoxide scavenging activity of matairesinol and oxidized matairesinol., Biosci. Biotechnol. Biochem., 70, 1934-1940, 2006.
    [PubMed 16926506]

  100. Molecular composition of non-ionic vesicles prepared from Span 80 or Span 85 by a two-step emulsification method., J. Disper. Sci. Technol., 27, 1217-1222, 2006.

  101. Immunostimulation effect of the fermented milk on human hybridomas and peripheral blood lymphocytes., Animal Cell Technology: Basic & Applied Aspects, Vol. 14, 185-191, 2006.

  102. Preparation of cationic immunovesicles containing cationic peptide lipid for specific drug delivery to target cells., Cytotechnology, 47, 51-57, 2005.
    [PubMed 19003044]

  103. Immunostimulation effects of proteose-peptone component 3 fragment on human hybridomas and peripheral blood lymphocytes., Biochim. Biophys. Acta, 1725, 233-240, 2005.
    [PubMed 15978734]

  104. Gene transfection into HeLa cells by vesicles containing cationic peptide lipid., Biosci. Biotechnol. Biochem., 69, 1453-1458, 2005.
    [PubMed 16116271]

  105. First enantioselective synthesis of (-)- and (+)-virgatusin, tetra-substituted tetrahydrofuran lignan., Org. Biomol. Chem., 3, 1670-1675, 2005.
    [PubMed 15858648]

  106. Identification of a novel zebrafish SULT1 cytosolic sulfotransferase: cloning, expression, characterization, and developmental expression study., Arch. Biochem. Biophys., 347, 10-19, 2005.
    [PubMed 15820212]

  107. Anti-cancer effect to colon cancer in either vitro or vivo using lipid vesicle combined with alga lectin ESA, Congress Proceedings of 10th The Asian Pacific Confederation of Chemical Engineering Congress, 1P-01-033, 1-10, 2004.

  108. Specific targeting at ERM5-1 cell as a model human-brain tumor cell and the anti-tumor effect by using immunovesicle, Congress Proceedings of 10th The Asian Pacific Confederation of Chemical Engineering Congress, 1P-01-032, 1-9, 2004.

  109. Lactate dehydrogenase enhances immunoglobulin production by human hybridoma and human peripheral blood lymphocytes., Cytotechnology, 42, 133-143, 2003.
    [PubMed 19002935]

  110. Sulphonation of Dehydroepiandrosterone and Neurosteroids: Molecular cloning, expression, and functional characterization of a novel Zebrafish SULT2Cytosolic Sulphotransferase., Biochem. J., 375, 785-791, 2003.
    [PubMed 12885295]

  111. Sulfonation of environmental estrogens by zebrafish cytosolic sulfotransferases., Biochem. Biophys. Res. Commun., 309, 7-11, 2003.
    [PubMed 12943655]

  112. Sulfation of hydroxychlorobiphenyls: molecular cloning, expression, and functional characterization of zebrafish SULT1 sulfotransferases., Eur. J. Biochem., 270, 2404-2411, 2003.
    [PubMed 12755695]

  113. cDNA Cloning, Expression, and Functional Characterization of A Zebrafish SULT1 Cytosolic Sulfotransferase., Arch. Biochem. Biophys., 414, 67-73, 2003.
    [PubMed 12745256]

  114. High IgM production by human-human hybridoma HB4C5 cells cultured in microtubes., Biosci. Biotechnol. Biochem., 67, 393-395, 2003.
    [PubMed 12729006]

  115. Differential roles of human monoamine (M)-form and simple phenol (P)-form phenol sulfotransferases in drug metabolism., J. Biochem.-Tokyo, 133, 259-262, 2003.
    [PubMed 12761191]

  116. Structure-function relationships in the stereospecific and manganese-dependent dopa/tyrosine sulfation by human M-form phenol sulfotransferase., J. Biol. Chem., 278, 1525-1532, 2003.
    [PubMed 12424257]

  117. Molecular cloning, expression, and functional characterization of a novel zebrafish cytosolic sulfotransferase., Biochem. Biophys. Res. Commun., 300, 725-730, 2003.
    [PubMed 12507510]

  118. Manganese stimulation and stereospecificity of the dopa/tyrosine-sulfating activity of human monoamine-form phenol sulfotransferase: kinetic studies of the mechanism using wild-type and mutant enzymes., J. Biol. Chem., 277, 43813-43820, 2002.
    [PubMed 12228221]

  119. Differential xenoestrogen-sulfating activities of the human cytosolic sulfotransferases: molecular cloning, expression, and purification of human SULT2B1a and SULT2B1b sulfotransferases., Biochim. Biophys. Acta,1573, 165-170, 2002.
    [PubMed 12399026]

  120. Heat denaturation enhanced immunoglobulin production stimulating activity of lysozyme from hen egg white., Biochim. Biophys. Acta, 1572, 19-24, 2002.
    [PubMed 12204328]

  121. Increase of immunoglobulin productivity of human-human hybridoma HB4C5 cells by histone., Biosci. Biotechnol. Biochem., 66, 1241-1245, 2002.
    [PubMed 12162544]

  122. Immunoglobulin production stimulating activity of heat-denatured lysozyme., Animal Cell Technology: Basic & Applied Aspects, Vol. 12, 179-183, 2001.

  123. The Cytotoxic effect of Eucheuma serra agglutinin (ESA) on cancer cells and its application to molecular probe for drug delivery system using lipid vesicles., Cytotechnology., 36, 93-99, 2001.
    [PubMed 19003319]

  124. Alcohol dehydrogenase-I from horse liver serves as an immunoglobulin production stimulating factor., Enzyme Microb. Technol., 29, 136-143, 2001.

  125. Application of the lipid vesicle immobilized Eucheuma sera lectin for target-specific drug delivery., Proc. of Biotechnology 2000 (The World Congress on Biotechnology), 83-85, 2000.

  126. Preparation of an immunovesicle for specific combining to target cells toward either DDS or gene transfection., Proc. of Biotechnology 2000 (The World Congress on Biotechnology), 79-81, 2000.

  127. The mode of actions of lysozyme as an immunoglobulin production stimulating factor., Biochim. Biophys. Acta, 1475, 27-34, 2000.
    [PubMed 10806334]

  128. Study of the specific binding between lipid vesicles and human-human hybridoma toward either DDS or gene transfection., Animal Cell Technology: Products from Cells, Cells as Products, 433-435, 1999.

  129. Study of DDS for cancer therapy applying lipid vesicle immobilizing Eucheuma Serra lectin., Animal Cell Technology: Products from Cells, Cells as Products, 429-431, 1999.

  130. The mode of actions of lysozyme as an immunoglobulin production stimulating factor (IPSF)., Animal Cell Technology: Products from Cells, Cells as Products, 43-45, 1999.

  131. Effects of DNA on immunoglobulin production stimulating activity of alcohol dehydrogenase., Cytotechnology, 31, 95-102, 1999.

  132. Aldolase from rabbit muscle enhances immunoglobulin production by human hybridoma and human peripheral blood lymphocytes., Enzyme Microb. Technol., 24, 41-47, 1999.

  133. Inhibition of immunoglobulin production stimulating activity of glyceraldehyde-3-phosphate dehydrogenase by nucleotides., Biosci. Biotech. Biochem., 62, 1237-1239, 1998.
    [PubMed 9692209]

  134. A novel function of enolase from rabbit muscle; an immunoglobulin production stimulating factor., Biochim. Biophys. Acta, 1380, 163-176, 1998.
    [PubMed 9565679]

  135. Spermine enhances IgM productivity of human-human hybridoma HB4C5 cells and human peripheral blood lymphocytes., Cytotechnology, 26, 111-118, 1998.

  136. Enhancement of immunoglobulin production of hybridomas and lymphocytes by alcohol dehydrogenase-I., Biochemical Engineering: Marching Toward The Century of Biotechnology, 157-160, 1997.

  137. Alcohol dehydrogenase-I from horse liver stimulates immunoglobulin production by human hybridoma and human peripheral blood lymphocytes., Mol. Cell. Biochem., 173, 113-119, 1997.
    [PubMed 9278261]

  138. Immunoglobulin production stimulating activities of basic proteins., Animal Cell Technology: Basic & Applied Aspects, Vol. 8, 209-215, 1997.

  139. Lysozyme stimulates immunoglobulin production by human-human hybridoma and human peripheral blood lymphocytes., Cytotechnology, 24, 177-182, 1997.

  140. Enhancement of IgM production by human peripheral blood lymphocytes by rice fermented seasoning under serum-free cultivation., J. Ferment. Bioeng., 82, 77-79, 1996.

  141. Effects of sodium poly(styrene sulfonate) on antibody production and cell growth HB4C5 hybridoma cells., Polym. J., 27, 719-727, 1995.

  142. Immunoglobulin production stimulating activities of nucleic acid-binding proteins., Animal Cell Technology: Developments towards the 21st Century, 501-507, 1995.

  143. Effects of organic pH buffers on cell growth and antibody production of human-human hybridoma HB4C5 cells in a serum-free culture., Cytotechnology, 17, 117-125, 1995.

  144. The mode of actions of glyceraldehyde-3-phosphate dehydrogenase identified as an immunoglobulin production stimulating factor., FEBS Lett., 368, pp.92-96, 1995.
    [PubMed 7615095]

  145. Removability and permeability of DNA in protein solution using BMM., Animal Cell Technology: Basic & Applied Aspects, Vol. 6, 543-547, 1994.

  146. Enhancement of immunoglobulin productivity of human-human hybridoma HB4C5 cells by basic proteins and poly-basic amino acids., Biosci. Biotechnol. Biochem., 58, 2212-2214, 1994.

  147. Synthesis of bis-piperazine-type pH buffer agents and their application to mammalian cell cultures., Biosci. Biotechnol. Biochem., 58, 1370-1375, 1994.

  148. Immunoglobulin production stimulating factor (IPSF) derived from Namalwa cells., Animal Cell Technology: Basic & Applied Aspects, Vol. 5, 601-607, 1993.

  149. Serum-free culture of human-human hybridoma secreting monoclonal antibody against stomach cancer., Animal Cell Technology: Basic & Applied Aspects, Vol. 4, 321-326, 1992.

  150. Virus containment continuous culture of animal cells., Animal Cell Technology: Basic & Applied Aspects, Vol. 4, 233-237, 1992.

  151. Purification and characterization of immunoglobulin production stimulating factor-IIβ derived from Namalwa cells., Cytotechnology, 10, 137-146, 1992.

  152. Purification and characterization of immunoglobulin production stimulating factor IIα derived from Namalwa cells., Production of Biologicals from Animal Cells in Culture, 735-741, 1991.

  153. Immunoglobulin production stimulating factor-IIα (IPSF-IIα) is glyceraldehyde-3-phosphate dehydrogenase like protein., Cytotechnology, 6, 115-120, 1991.

  154. Large-scale, high-density freezing of hybridomas and its application to high-density culture., Biotechnol. Bioeng., 38, 1110-1113, 1991.

  155. Purification of immunoglobulin production stimulating factor IIα derived from Namalwa cells., Cytotechnology, 5, 255-263, 1991.

  156. Enhancement of immunoglobulin production of human-human hybridomas by immunoglobulin production stimulating factors., Trends in Animal Cell Culture Technology, 291-297, 1990.

  157. Relationship between oxygen consumption rate and cellular activity of mammalian cells culturedin serum-free media., Biotechnol. Bioeng., 36, 759-762, 1990.

  158. Purification and characterization of immunoglobulin production stimulating factor derived from human B lymphoblastoid HO-323 cells., Cytotechnology, 3, 189-197, 1990.

  159. Stimulation of proliferation and immunoglobulin M production by lactoferrin in human-human and mouse-mouse hybridomas cultures in serum-free conditions., Cytotechnology, 3, 123-131, 1990.

  160. Screening of immunoglobulin production stimulating factor (IPSF) in foodstuffs using human-human hybridoma HB4C5 cells., Agric. Biol. Chem., 53, 2987-2991, 1989.

  161. Stimulation of monoclonal antibody production by human-human hybridoma cells with an elevated concentration of potassium or sodium phosphate in serum-free medium., Cytotechnology, 2, 63-67, 1989.

  162. Partial purification and characterization of immunoglobulin production stimulating factor derived from Namalwa cells., In Vitro Cell. Develop. Biol., 25, 243-247, 1989.

    〜研究テーマのページで要旨公開中〜

著 書
  1. 「第2章 第4節 [7] 培養装置による動物細胞の大量培養」、動物細胞培養の手法と細胞死・増殖不良・細胞変異を防止する技術、技術情報協会、p. 231-236、2014

  2. 「第2編 細胞培養法による製造 第4章 高密度培養法」、バイオ医薬品製造の効率化と生産基材の開発、シーエムシー出版、p. 55-60、2012.

  3. 「第13章 柑橘成分の生体調節機能」、食と健康を支援する 第2集、山田耕路編著、門司印刷、p. 153-166、2012.

  4. 「動物細胞を用いた機能性評価 HB4C5細胞を用いた抗体産生促進活性測定法」、食品機能性評価マニュアル集 第3集、食品機能性評価支援センター編、p. 95-104、2009.

  5. 「第3章 ハイブリドーマによるモノクローナル抗体生産性の増強」、生物機能研究会シリーズ1 生物機能研究の進歩1(生物機能研究会編)、アイピーシー、p. 117-136、2002.

  6. 「抗体産生促進因子」(p. 149-150)、「高密度培養」(p. 165-166)、「生理活性物質の単離精製」(p. 170-171)、動物細胞工学ハンドブック、朝倉書店、2000.

  7. 「第3章 動物系バイオインダストリー」、新産業化学シリーズ ニューバイオインダストリー、大日本図書、p. 109〜160、1997.

  8. 「細胞工学概論」、コロナ社、p. 1-207、1994.

  9. 「第3章 動物細胞培養法」、化学と生物実験ライン25 動物細胞培養技術、廣川書店、p. 27-42、1992.

総 説

  1. 「愛媛の柑橘果皮を活用した機能性食品開発」, 地方創生に関わる生物工学の取り組み ー日本各地の活動とネットワークの必要性ー, 日本生物工学会編, 58-60, 2016.
  2. 「愛媛大学における機能性食品開発」, 栄養教諭, 45(10), 42-45, 2016.
  3. 「ミカン果皮の機能性と商品開発」, 食品と開発, 51(10), 64-66, 2016.
  4. 「ブリ心臓でヒトの免疫促進 -加工残渣の有効活用-」、 月刊養殖、49、30-33、2012.
  5. 「温州ミカン果皮成分の免疫促進活性」、 月刊FOOD STYLE21、16、45-47、2012.
  6. 「水産物資源の有効活用に関する研究 -ハマチ心臓、マグロ動脈球の免疫促進活性について-」、 生物機能研究、15、24-30、2011.
  7. 「動物細胞と実験動物を用いた生理活性物質の機能解明」、月刊愛媛ジャーナル、22、60-63、2009.

  8. 「界面活性剤を利用したナノカプセルによる薬物運搬体および遺伝子導入体の開発」(共著)、化学と教育、55、184-187、2007.

  9. 「食品タンパク質およびペプチドの免疫調節機構」(共著)、生物機能研究会誌、6、25-31、2002.

  10. 「癌細胞への標的機能を有する脂質膜ベシクルの創製」(共著)、化学工学シンポジウムシリーズ、76、230-238、2001.

  11. 「癌治療DDSへの利用を目指した脂質ベシクルの創製」(共著)、ケミカルエンジニアリング、45(6)、49-55、2000.

  12. 「ヒト型ハイブリドーマの抗体産生促進機構に関する研究」、日本農芸化学会誌、74, 1107-1112, 2000.

  13. 「ハイブリドーマによるモノクローナル抗体の効率的生産に関する研究」、日本農芸化学会誌、74、986-989、2000.

  14. 「モノクローナル抗体生産性の増強」、生物機能研究会誌、2、18-23、1998.

  15. 「レーザー共焦点顕微鏡による蛍光観察」、生物機能研究会誌、2、60-64、1998.

  16. 「コメ発酵エキス中の増殖促進因子、および抗体産生促進因子の検索」、日本農芸化学会誌、70、801-802、1996.

  17. Immunoglobulin production stimulating factors., Cell Biology and Biotechnology: Novel Approaches to Increased Cellular Productivity, 35-62, 1993.

特 許
登録特許・商標

  1. 菅原卓也・門田 歩・山内 聡・西脇 寿・川合研兒・大島俊一郎「免疫蛋白質の産生促進剤」(特許第5981114号)(2016年8月5日登録)
  2. 四国乳業株式会社・愛媛大学・伊方サービス株式会社:N+ (エヌプラス)(商標第5849663号) (2016年5月13日登録)

  3. 菅原卓也・門田 歩:免疫蛋白質の産生促進剤(特許第5688697号)(2015年2月6日登録)
  4. 菅原卓也:免疫賦活活性剤:「アレルギー抑制活性剤、抗ガン活性剤および医薬品」特許第5177468号(2013年1月18日登録)
  5. 菅原卓也・土居幹治・白石隆介:「細胞傷害性活性を作用させるための水溶性画分」特許第5137098号(2012年11月22日登録)
  6. 菅原卓也・土居幹治・白石隆介:「細胞壊死活性のための有機溶媒画分」特許第4974020号(2012年4月20日登録)
  7. 加藤敬一・小稲則夫・菅原卓也:「脂質ベシクルおよび脂質ベシクルの製造方法」特許第4928689号(2012年2月17日登録)
  8. 菅原卓也・土居幹治・白石隆介:「免疫調節作用を有する化合物」特許第4888687号(2011年12月22日登録)

  9. 菅原卓也・原 和志・中本勝教:「免疫増強組成物」特許第4688457号(2011年2月25日登録)

  10. 菅原卓也・山内 聡・秋山浩一・土居幹治・白石隆介:「免疫調節蛋白質の製造方法」特許第4656300号(2011年1月7日登録)

公開特許・出願特許

  1. 「マクロファージ活性化剤」特願2015-202454(2015年10月13日出願)
  2. 「アレルギー症状緩和剤」特願2015-202449(2015年10月13日出願)
  3. 「マクロファージの活性促進剤および脱顆粒抑制剤」特願2015-176263(2015年9月9日出願)
  4. 「脱顆粒抑制剤」特願2015-176262(2015年9月9日出願)
  5. 「抗アレルギー用経口組成物」特開2015-36369(2015年2月23日公開)
  6. 「抗アレルギー剤」特開2015-10041(2015年1月19日公開)
  7. 「カビおよびカビ培養抽出物」特開2012-231679(2012年11月29日公開)
  8. 「免疫蛋白質の産生促進剤、および免疫蛋白質の産生促進方法」特開2012-180303(2012年9月20日公開)
  9. 「魚介類用飼料添加剤およびこれを用いた魚介類用飼料」特開2012-157338(2012年8月23日公開)
  10. 「免疫促進剤およびその製造方法」特開2012-111698(2012年6月14日公開)
  11. 「アレルギー抑制剤」特開2011-178750(2011年9月15日公開)
  12. 「免疫蛋白質の産生促進剤」特開2011-116735(2011年6月16日公開)
  13. 「クラゲコラーゲンを含む免疫活性増強剤」特開2010-173937(2010年8月12日公開)
  14. 「生理活性物、それを含むアレルギー抑制活性剤、免疫調整剤、飲食品、サプリメントおよび医薬品」特開2010-116391(2010年5月27日公開)
  15. 「魚肉の褐変防止剤および褐変防止方法」 特開2010-057367(2010年3月18日公開)
  16. 「免疫蛋白質の製造方法」特開2008-212026(2008年9月18日公開)
  17. 「脂質膜ベシクルおよびその調製法」:特開2005-068120(2005年3月17日公開)
  18. 「脂質膜ベシクルおよび遺伝子を固定化する方法」特開2003-012503(2003年1月15日公開)
  19. 「標的指向性を有するベシクル及びその調製法」特開2001-181213(2001年7月3日公開)

受 賞
  1. 愛媛新聞社 愛媛農林水産賞 技術開発賞 (2016年)

  2. International Conference on Food Factors (ICoFF) 2011 Poster Award, "Effect of flaxseed lignan on lipid accumulation in adipocytes."(2011年)

  3. 日本農芸化学会 日本農芸化学奨励賞(2000年)


mars95@agr.ehime-u.ac.jp