Biosci. Biotech. Biochem., 70, 2131-2137, 2006. [PubMed 16960386]

Immunostimulation effect of the jellyfish collagen.

Takuya Sugahara, Masashi Ueno, Yoko Goto, Ryusuke Shiraishi, Mikiharu Doi, Koichi Akiyama, and Satoshi Yamauchi


Some edible large jellyfishes belonging to the order Rhizostomeae are consumed in large quantities in China and Japan. The exumbrella part of the edible jellyfish Stomolophus nomurai was cut and soaked in dilute hydrochloric acid solution (pH 3.0) for 12 h, and heated at 121C for 20 min. The immunostimulation effects of the jellyfish extract were examined. The jellyfish extract enhanced IgM production of human hybridoma HB4C5 cells 34-fold. IgM and IgG production of human peripheral blood lymphocytes (PBL) were also accelerated 2.8- and 1.4-fold, respectively. Moreover, production of interferon (IFN)- and tumor necrosis factor (TNF)- by human PBL was stimulated 100- and 17-fold, respectively. Collagenase treatment inactivated the immunostimulation activity of the jellyfish extract. In addition, purified collagen from bovine Achillesf tendon accelerated IgM production of hybridoma cells. These facts mean that collagen has immunostimulation effect, and the active substance in jellyfish extract is collagen.